If it's not a demylination issue - here's what it sounds like to me because a 22 year old doesn't just get stroke like symptoms. Concussion trajectories and brain inflammation are similiar to what can happen to kids with autism. Potentially he has a neurologically vulnerable system that has now been tipped into dysfunction. Five concussions in a year puts the brain under significant cumulative stress. I've tried to explain for you Concussion, cumulative brain injury and neuro-inflammation. There's a lot of research on it these days. What that means is: - The brain becomes more sensitive and reactive to triggers - Its protective barrier is weakened, so it’s more exposed to inflammation - Its energy production drops, so it can’t function as efficiently The brain is easier to tip into dysfunction and slower to recover when stressed. Then as you know - the gut is a major regulator of the immune and nervous systems, so when it’s disrupted, the brain feels it. He has possibly had leaky gut for sometime. Probably from a great number of antibiotics of his life, or high stress, or terrible diet - all create permeability. then - Infection → activates the immune system via the gut - Amoxicillin → alters the microbiome balance - This can lead to:Increased inflammatory signalling - Increased histamine release - Changes in gut–brain communication (vagus nerve + cytokines) If the gut becomes more permeable (“leaky”), more inflammatory signals reach the brain In a primed brain (post-concussion): - These signals are amplified - The brain is more likely to shift into neuroinflammation or dysfunction Meaning - In a sensitised brain, infection and antibiotics amplify neuroinflammation This can lead to dysfunction in specific brain areas, which is why you see focal symptoms like one leg being affected.” - Motor + sensory changes → central involvement - Not peripheral, not just mechanical The relapse pattern is what concerns me Jordie —it suggests central involvement rather than just a functional or mechanical issue.

HI @Jordie Watkins no not really. He could test but just ask him questions about skin reactions to foods, bites etc, gut reactions to food (wine, eggs, onions etc), seasonal reactions etc HOPEFULLY he doesn't have histamine issues because that means how we approach with replenishing his NS is more straight forward.

HI @Bridget Melling-Williams if you've checked his hips and they seem fine - yes to checking S2 and ironing that out potentially he was breech. That often creates that S2 wedging. Have you been doing Logan on him? I would do that consistently. Perhaps you're also checking and working on his sphenoid - that often results in the poor sucking? Makes sense that would be flexion. Does he have a tongue tie or tight tongue? You can work under the tongue. I'd also tried some sutural spreading. Also teach the parents to hold him outwards against their chest and bring his legs up holding them at the thighs and just holding them there - this creates a gentle stretch through the dura. It should get easier if they do a number of times a day. Also sounds like Mum and bub are probably deficient in certain things. If it feels right and when the timing is right - see if she's open to adding to his formula. I'd be recommending 1/3 teaspoon of straight glycine powder into his formula twice a day and 1/3 magnesium gylcinate powder at night into his formula

Such a common presentation, @Ben McDonell . One way I tend to think about endometriosis (outside of just hormones/insulin) is that the body is struggling to keep inflammation and repair in balance. From a methylation perspective, a lot of these cases look like high demand rather than simple deficiency. There’s often ongoing inflammation, so the body is constantly trying to make enough glutathione to put those “fires” out. That can chew through methyl donors pretty quickly. On top of that, you can have immune patterns (IL-6 type activity) where the system is really effective… but doesn’t switch off easily. So if there’s something like gut or thyroid dysfunction in the background, it just keeps that fire going. I also find neurotransmitter sensitivity plays a role in some of these patients — they can be quite reactive, which again increases demand on methylation. So you end up with this picture where the body is trying to juggle: - Inflammation - Repair - Nervous system sensitivity - And SNPs in folate/choline pathways …and it’s just constantly trying to keep up. The tricky part is that a lot of these patients are high demand but also high sensitivity, so they don’t always tolerate strong or fast-acting interventions well. That can include some of the more heavily methylated supplements, which for certain individuals may feel a bit too stimulating. That’s where I find asking about mood/stress response, gut symptoms, reactions to sulphur foods or detox protocols can give you a good sense of how much you can “push” things. If they are quite sensitive in that space, you’ll often find glutathione products don’t go well, which is a helpful clue. From a general support point of view (keeping it broad), I tend to think in terms of: - Building a really solid nutritional base that supports methylation (good quality animal protein, gelatinous cuts, eggs, seafood, dairy if tolerated) - Making sure they’ve got enough easy energy coming in (carbs for thyroid support — fruit, root veg, rice, etc.) - Keeping fats balanced and generally minimising PUFA load

Start with Food Foundations Focus on broadening your intake of nutrients required for methylation, including: - vitamin B9 (folate) - vitamin B12 - vitamin B2 - vitamin B6 - choline - glycine Food sources include: Protein-rich foods - eggs - red meat - liver and organ meats - shellfish Choline-rich foods - egg yolks - liver - dairy Glycine-rich foods - slow-cooked meats - gelatinous cuts - meat broths These nutrients provide the building blocks required for: - neurotransmitter production - detoxification pathways - nervous system stability Eat Enough and Include the Right Carbohydrates Methylation and nervous system regulation are energy-dependent. If you are: - under-eating - skipping meals - avoiding carbohydrates …the body will rely more heavily on stress hormones. This increases: - nervous system activation - histamine activity - overall system load Support this by: - eating regular meals - ensuring adequate calorie intake - including easy-to-digest carbohydrates (fruit, root vegetables) This helps: - stabilise blood sugar - reduce stress hormone output - support mitochondrial energy production Targeted Support (When Needed) Once food foundations are in place, some people benefit from additional support. This may include: - a high-quality multivitamin - methylation-support nutrients (introduced gradually) - magnesium - glycine In sensitive individuals, particularly those with SNPs affecting methylation pathways: - start low - build gradually - consider methyl-free forms (folinic acid, hydroxy B12) Some people notice that as these pathways are supported:→ their overall stress tolerance improves→ their nervous system feels calmer The external stress may not change —but their capacity to handle it does.

In short you might both feel calmer and sturdier with these foods and supps.