@Bobbi Colhour it depends on your personal reaction to the injection. I added 3ml and that was fine for me. I did notice that injecting my thighs caused more burn and my abdomen didn’t. So I just rotated around my belly button area and stopped injecting my thigh. Some folks find that they need to dilute more than the 3ml to avoid the sting/burn reaction. Regarding dosing, I started with 7.5 and never went higher than 15 and I had noticeable reduction in pain and inflammation in my injured knee. I’m only 100 pounds , 5 feet so staying on the lower dosage seemed to be plenty effective for me. YMMV