Antioxidants, Polyphenols, and Cancer Therapies
There’s often confusion about how antioxidants or polyphenols might interact with cancer treatments like immunotherapy, chemotherapy, or pro-oxidant therapies (IV Vitamin C, HBOT, Artemisinin, Methylene Blue + light). The scientific literature suggests that timing can influence how these compounds behave in the body. ✅ Immunotherapy (e.g. Keytruda, Opdivo) - These drugs reactivate T-cells, which use bursts of reactive oxygen species (ROS) to attack tumors. - Some studies suggest that very strong antioxidants (Vitamin C, NAC, glutathione, Vitamin E) could, if taken right at infusion, reduce this ROS signal. - Polyphenols (curcumin, EGCG, resveratrol, quercetin) act differently. They don’t just “scavenge ROS” but instead modulate pathways like NF-κB and STAT3. Literature suggests they may even support immune function during checkpoint inhibitor therapy. ✅ Chemotherapy (platinums, taxanes, anthracyclines, etc.) - Many chemotherapies kill cancer cells through oxidative stress. - Strong antioxidants given at the same time could theoretically reduce this effect, which is why some protocols separate them by a day or two. - Polyphenols are more nuanced: some studies show they can reduce side effects and may even increase cancer sensitivity to chemo, but timing still appears to matter. ✅ Pro-oxidant Therapies (IV Vitamin C, HBOT, Artemisinin, CDS, Methylene Blue + light) - These therapies aim to increase ROS stress in cancer cells. - Combining them with strong antioxidants in the same window may cancel out the intended effect. - Polyphenols don’t appear to block this process and in some contexts have been reported to enhance it. ✅ Key Idea - Classical antioxidants (Vitamin C, NAC, glutathione, ALA, Vitamin E) directly scavenge ROS, which can interfere with therapies that rely on oxidative stress if taken at the same time. - Polyphenols (curcumin, EGCG, resveratrol, quercetin) act more like signaling regulators and are generally reported as supportive rather than disruptive.