For today’s “Peptide of the Day,” we’re diving deep into GHK-Cu (also known as Copper Peptide or Gly-His-Lys-Copper). This powerhouse has been buzzing in the anti-aging and wellness world for its regenerative magic. Whether you’re into skin glow-ups, hair hacks, or faster healing, GHK-Cu might just be your new bestie. Let’s break it down step by step – based on solid literature and research. What is GHK-Cu? 🤔 GHK-Cu is a naturally occurring tripeptide (a tiny chain of three amino acids: glycine, histidine, and lysine) bound to a copper ion. It’s found in your body’s plasma, saliva, and urine, but levels drop by over 60% as you age (starting around 60, per studies). Discovered in the 1970s by Dr. Loren Pickart, it was first noted for making old liver cells act young again. Today, it’s a star in cosmetics, injectables, and therapies for its protective and rebuilding properties. Think of it as your body’s built-in repair kit! How Does It Work? 🧬 GHK-Cu is a gene-modulator extraordinaire. It flips switches in your cells to promote healing and regeneration. Here’s the science: - Stimulates growth factors: Boosts collagen, elastin, and glycosaminoglycan production (the stuff that keeps skin plump and joints healthy). - Promotes angiogenesis and nerve outgrowth: Helps form new blood vessels and nerves for better tissue repair. - Anti-inflammatory and antioxidant: Suppresses inflammation genes, fights free radicals, and resets damaged cells. - Tissue remodeling: Activates genes for repair while shutting down ones linked to breakdown and aging. From NIH-backed research (like a 2018 review in Frontiers in Pharmacology), it supports fibroblast function (skin-building cells) and even reverses some age-related gene changes. It’s like giving your body a “reset” button at the cellular level! Main Effects & All the Benefits from Literature 💪 The hype is real – GHK-Cu has been studied extensively for decades. Here’s a roundup of its top benefits, pulled from peer-reviewed lit (e.g., PubMed, animal/human trials, and reviews):