Many parents are concerned with the presence or experience with side effects whe starting on Folinic Acid or Leucovorin. From Dr. Frye's studies we see that typically behaviors of excitement or aggitation resolve within about 3 weeks from onset. This is without any additional supplements or interventions being added to regimen. Please keep this in mind if you see behaviors starting to "get worse" when starting on Folinic Acid or Leucovorin. Please always follow up with your established healthcare provider if you notice any concerning symptoms. https://pmc.ncbi.nlm.nih.gov/articles/PMC7477301/