1. Cellular Energy Deficiency (Mitochondrial Stress — The #1 Root Cause)
Your cells sense danger when they cannot produce enough ATP (Energy within the Cell).
Low energy = threat = inflammation triggered to protect tissues.
Primary causes of mitochondrial stress-
- Chronic stress
- Poor sleep or circadian disruption
- Nutrient deficiencies (magnesium, B vitamins, CoQ10, carnitine)
- Toxins (plastics, mold, heavy metals, xenoestrogens)
- Seed oils (PUFAs causing oxidative stress)
- Low thyroid function
- Alcohol
- Overtraining or under-eating
- Viral or bacterial load
- Aging + inflammation load
When energy drops, inflammation rises.
2. Blood Sugar & Insulin Instability
The body interprets unstable blood sugar as an emergency.
Caused by-
- Excess carbs without protein
- Insulin resistance
- Cortisol spikes
- Skipping meals
- Nighttime eating
- Poor sleep
- Chronic stress
- Excessive snacking
- High PUFA diet
This is the fastest way to trigger chronic low-grade inflammation.
3. Gut Barrier Dysfunction (“Leaky Gut”)
When the gut lining breaks down, food particles, toxins, and microbes leak into the bloodstream leading to immune activation leading to inflammation.
Primary triggers-
- Gluten
- Alcohol
- Seed oils
- Artificial sweeteners
- Food sensitivities
- Antibiotics
- Processed foods
- Stress
- Gut infections
- Low stomach acid
- Mold + environmental toxins
About 70–80% of the immune system sits in the gut.
If the gut is inflamed, everything becomes inflamed.
4. Chronic Psychological + Emotional Stress
The nervous system controls the immune system.
High stress leads to high cortisol leads to immune dysregulation which leads to inflammation.
It's caused by-
- Trauma
- Grief
- Chronic overwhelm
- Perfectionism
- Burnout
- Work stress
- Mother-load stress
- Marriage or relationship pressures
- Financial fear
- Chronic fear/shame loops
This root cause is massively underestimated in women over 40.
5. Environmental Toxic Load
These overwhelm detox pathways lead to mitochondrial stress which lead to inflammation.
Just some of the Major toxins-
- Plastics (phthalates, BPA)
- Mold
- Heavy metals (mercury, cadmium, lead)
- Pesticides + herbicides
- Air pollution
- Fragrances
- Household cleaners
- Skincare + makeup chemicals
- Degassing furniture
- EMF overload - don't discount this one from phones/smart meters, electricity in the home & workplace. Even your Electric Vehicle.
The more toxins the body must process, the more inflammation it produces.
6. Light, Sleep, and Circadian Rhythm Disruption
Circadian mismatch destabilizes hormones, blood sugar, and mitochondria.
Caused by-
- Blue light at night, lights
- Screens before bed - TV, I-pad, phone
- Missing morning sunlight
- Shift work
- Jet lag
- Irregular sleep times
- Insufficient sleep
- High nighttime cortisol
Your circadian rhythm controls inflammation genes.Out of sync rhythm = an inflamed body.
7. Nutrient Deficiencies
Low nutrients lead to weak mitochondria lead to low energy which leads to inflammation.
Most common deficiencies in women over 40-
- Magnesium
- Vitamin D
- Protein
- Omega-3s
- B12 + Folate
- Potassium
- Selenium
- Zinc
- Vitamin C
Your immune system CANNOT regulate inflammation without the proper nutrients.
If you can't get them from food, don't self medicate, talk with a Health Supplement Professional
8. Hormonal Imbalances (Especially in Women 40+)
Hormonal shifts create metabolic stress leads to inflammatory response.
Core issues are -
- Low progesterone
- Estrogen dominance
- Low estrogen after menopause
- High cortisol
- Low thyroid (subclinical or clinical)
- Low testosterone
- Insulin resistance
- Leptin resistance
Hormones are the inflammation thermostat.
Unbalanced hormones lead to a higher inflammation baseline.
BONUS ROOT CAUSES- The Silent Ones Most People Miss
9. Chronic Infections (often low-grade)
- EBV
- CMV
- Lyme
- H. pylori
- SIBO
- Candida
- Dental infections
- Root canal bacteria
- Viral reactivation
10. Foreign Bodies / Implants / Medical Devices
These act as constant immune triggers-
- Breast implants
- IUDs (in some women)
- Dental implants
- Joint implants
- Organ Implants
- Heart Valve Implants
- Mesh
- Silicone
- Fillers
This is autoimmune fuel for Women with genetic susceptibility.
11. Sedentary Lifestyle
Low movement leads to low anti-inflammatory signaling from muscle (myokines).
12. Over-exercise - very common
Too much stress leads to mitochondrial damage leading to inflammation.
13. Poor Detox Pathways
If the liver, lymph, kidneys, or gut are overburdened, inflammation increases.
Each of these are forms of Stress.
Which ones can you change or remove from YOUR Life today?