Mar 30 • Peptide Research
Growth Hormone Secretagogues Compared: Sermorelin vs CJC-1295 vs Ipamorelin
Not all GH secretagogues work the same way. Here's a research-based comparison.
SERMORELIN (GHRH Analog)
- Mechanism: Mimics natural GHRH, signals pituitary to release GH
- Evidence level: Highest among secretagogues (was FDA-approved, well-studied)
- Administration: Subcutaneous injection
- GH release pattern: Maintains natural pulsatile release
- What ElevateMD prescribes: Yes — core component of the Longevity Stack
CJC-1295 (Modified GHRH Analog)
- Mechanism: Extended half-life GHRH analog (with or without DAC modification)
- Evidence level: Moderate — clinical studies exist but fewer than Sermorelin
- Key difference: Longer half-life means sustained GH elevation vs pulsatile
- Note: The DAC version creates continuous GH elevation, which may not be physiologically ideal
IPAMORELIN (Ghrelin Mimetic / GHSR Agonist)
- Mechanism: Stimulates GH release through a DIFFERENT pathway (ghrelin receptor)
- Evidence level: Moderate — clinical studies show selective GH release
- Key advantage: Very selective — minimal effect on cortisol and prolactin
- Often combined with CJC-1295 for dual-pathway stimulation
WHY MECHANISM MATTERS
Sermorelin works through the GHRH pathway. Ipamorelin works through the ghrelin pathway. These are different biological systems with different downstream effects.
OUR APPROACH
We start with what has the strongest evidence (Sermorelin) and build from there based on your labs and response. We don't stack compounds without clinical justification.
What questions do you have about the differences between these compounds?
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Growth Hormone Secretagogues Compared: Sermorelin vs CJC-1295 vs Ipamorelin
