Lesson 14: The Peptides That Control Growth Hormone (GH): Sermorelin, Tesamorelin, Ipamorelin, and Hexarelin

Nov 11 (edited) • General discussion

In today’s lesson, I break down how different peptides stimulate growth hormone and why they aren’t all the same.

You’ll learn:

The two different receptors on the pituitary that control GH release GHRH receptor (Sermorelin, Tesamorelin) GHRP / Ghrelin receptor (GHS-R1a) (Ipamorelin, Hexarelin)
Why GHRH peptides are like the offensive coordinator (calling the play)
Why GHRP peptides are like the quarterback taking a direct snap (fast GH dump)
How Hexarelin is different: it has human data showing improved cardiac function (↑ ejection fraction) through ghrelin receptors on heart muscle
Why business, not science, kept some of these from becoming approved therapies

My goal with this lesson:

▶ Help you understand where each peptide works in the pathway

▶ Help you make logical decisions about GH/IGF optimization

▶ Eliminate the confusion and bro-science around peptides

If you understand this pathway, you’ll never be sold “random peptide stacks” again: you’ll know exactly what lever you’re pulling and why.

8:08

4 comments